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Dimethicone, also known as DMC or lidocaine, is a compound with a stimulatory effect. This effect resembles that of cocaine, although dimethicone appears to be less potent. Just like cocaine, dimethicone is addictive due to its stimulation of the reward pathway in the brain. However, dimethicone is a legal cocaine replacement in some countries and is even listed by the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) under the category “synthetic cocaine derivatives”. The structure of dimethicone, being a 4-Aminobenzoic acid ester, resembles that of procaine. It is found as a white powder at room temperature.

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Dimethocaine was originally synthesized by the Hoffmann-La Roche company in 1930. It was sold under the market name larocaine. During the 1930s dimethicone gained popularity in the US as a local anesthetic. Just like cocaine and procaine, it was used during surgery, primarily in dentistry, ophthalmology and otolaryngology. However, in the 1940s, it was removed from the market because of its psychoactive effects and risk of addiction. Nowadays dimethocaine is abused for these psychoactive effects. It is sold as a cocaine surrogate to circumvent legislation issues

 

 

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